Below is a list of Selected Publications from the Puglielli Lab.
Fernandez-Fuente G, Farrugia MA, Peng Y, Schneider A, Svaren J, Puglielli L. Spatial selectivity of ATase inhibition in mouse models of Charcot-Marie-Tooth disease. Brain Commun. 2024 Jul 9;6(4):fcae232. doi: 10.1093/braincomms/fcae232. PMID: 39035418; PMCID: PMC11258571.
Xu S, Zhu Z, Delafield DG, Rigby MJ, Lu G, Braun M, Puglielli L, Li L. Spatially and temporally probing distinctive glycerophospholipid alterations in Alzheimer’s disease mouse brain via high-resolution ion mobility-enabled sn-position resolved lipidomics. Nat Commun. 2024 Jul 24;15(1):6252. doi: 10.1038/s41467-024-50299-9. PMID: 39048572; PMCID: PMC11269705.
Fernandez-Fuente G, Overmyer KA, Lawton AJ, Kasza I, Shapiro SL, Gallego-Muñoz P, Coon JJ, Denu JM, Alexander CM, Puglielli L. The citrate transporters SLC13A5 and SLC25A1 elicit different metabolic responses and phenotypes in the mouse. Commun Biol. 2023 Sep 9;6(1):926. doi: 10.1038/s42003-023-05311-1. PMID: 37689798; PMCID: PMC10492862.
Zhang H, Liu Y, Fields L, Shi X, Huang P, Lu H, Schneider AJ, Tang X, Puglielli L, Welham NV, Li L. Single-cell lipidomics enabled by dual-polarity ionization and ion mobility-mass spectrometry imaging. Nat Commun. 2023 Aug 25;14(1):5185. doi: 10.1038/s41467-023-40512-6. PMID: 37626051; PMCID: PMC10457347.
Fernandez-Fuente G, Rigby MJ, Puglielli L. Intracellular Citrate/acetyl-CoA flux and endoplasmic reticulum acetylation: Connectivity is the answer. Mol Metab. 2023 Jan;67:101653. doi: 10.1016/j.molmet.2022.101653. Epub 2022 Dec 10. PMID: 36513219; PMCID: PMC9792894.
Murie M, Peng Y, Rigby MJ, Dieterich IA, Farrugia MA, Endresen A, Bhattacharyya A, Puglielli L. ATase inhibition rescues age-associated proteotoxicity of the secretory pathway. Commun Biol. 2022 Feb 25;5(1):173. doi: 10.1038/s42003-022-03118-0. PMID: 35217767; PMCID: PMC8881600.
Rigby MJ, Orefice NS, Lawton AJ, Ma M, Shapiro SL, Yi SY, Dieterich IA, Frelka A, Miles HN, Pearce RA, Yu JPJ, Li L, Denu JM, Puglielli L. Increased expression of SLC25A1/CIC causes an autistic-like phenotype with altered neuron morphology. Brain. 2022 Apr 18;145(2):500-516. doi: 10.1093/brain/awab295. PMID: 35203088; PMCID: PMC9014753.
Rigby MJ, Orefice NS, Lawton AJ, Ma M, Shapiro SL, Yi SY, Dieterich IA, Frelka A, Miles HN, Pearce RA, Yu JPJ, Li L, Denu JM, Puglielli L. SLC13A5/sodium-citrate co-transporter overexpression causes disrupted white matter integrity and an autistic-like phenotype. Brain Commun. 2022 Jan 5;4(1):fcac002. doi: 10.1093/braincomms/fcac002. PMID: 35146426; PMCID: PMC8823335.
Sheehan BK, Orefice NS, Peng Y, Shapiro SL, Puglielli L. ATG9A regulates proteostasis through reticulophagy receptors FAM134B and SEC62 and folding chaperones CALR and HSPB1. iScience. 2021 Mar 16;24(4):102315. doi: 10.1016/j.isci.2021.102315. PMID: 33870132; PMCID: PMC8042170.
Rigby MJ, Lawton AJ, Kaur G, et al. Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism. Commun Biol. 2021;4(1):454. Published 2021 Apr 12. doi:10.1038/s42003-021-01992-8
Sheehan BK, Orefice NS, Peng Y, Shapiro SL, Puglielli L. ATG9A regulates proteostasis through reticulophagy receptors FAM134B and SEC62 and folding chaperones CALR and HSPB1. iScience. 2021;24(4):102315. Published 2021 Mar 16. doi:10.1016/j.isci.2021.102315
Dieterich IA, Cui Y, Braun MM, et al. Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway. Sci Rep. 2021;11(1):2013. Published 2021 Jan 21. doi:10.1038/s41598-021-81447-6
Farrugia MA, Puglielli L. Nε-lysine acetylation in the endoplasmic reticulum: a novel cellular mechanism that regulates proteostasis and autophagy. Journal of Cell Science 2018 (link: J Cell Sci 2018).
Dieterich IA, Lawton AJ, Peng Y, Yu Q, Rhoads TW, Overmyer KA, Cui Y, Armstrong EA, Howell PR, Burhans MS, Li L, Denu JM, Coon JJ, Anderson RM, Puglielli L. Acetyl-CoA flux regulates the proteom and acetyl-proteome to maintain intracellular metabolic crosstalk. Nature Communications 2019 (link: Nat Commun 2019).
Peng Y, Shapiro SL, Banduseela VC, Dieterich IA, Hewitt KJ, Bresnick EH, Kong G, Zhang J, Schueler KL, Keller MP, Attie AD, Hacker TA, Sullivan R, Kielar-Grevstad E, Arriola Apelo SI, Lamming DW, Anderson RM, Puglielli L. Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype. Aging Cell 2018 (link: Aging Cell 2018).
Hullinger R, Li M, Wang J, Peng Y, Bomba E, Dowell J, Mitchell HA, Burger C, Chapman E, Denu J, Li L, Puglielli L. Increased influx of acetylCoA into the ER lumen causes autism spectrum disorder and mental retardation. Journal of Experimental Medicine 2016 (link: J Exp Med 2016).
Peng Y, Kim MJ, Hullinger R, O’Riordan KJ, Burger C, Pehar M, Puglielli L. Improved proteostasis in the secretory pathway rescues Alzheimer’s disease in the mouse. Brain 2016 (link: Brain 2016).